British Air Force Typhoon jets have operated alongside France's air force in a combined operation on an hidden munitions depot in Syria employed by the IS group, according to the British defence ministry.
The location, pinpointed through surveillance, was assessed as storing arms and explosives, the release indicated, and was situated in hills just north of the historic site of Palmyra in the heart of Syria.
"The RAF jets employed Paveway IV guided bombs to target a number of access tunnels providing entry to the facility... early reports are that the objective was successfully hit," officials stated.
There was no sign of any harm to civilians in the attack conducted Saturday night and every plane involved returned to base without incident, the ministry further stated.
The Typhoon fighters were supported by a Voyager aerial refuelling aircraft.
IS - referred to as Daesh - established militant control over large swathes of both Syria and Iraq until 2019.
"This operation shows the UK's leading role, and resolve to work closely with allied nations, to stamp out any revival of the terrorist group and their dangerous and violent ideologies in the region," UK Defence Secretary John Healey said.
British military aircraft have conducted surveillance missions over Syria to "deter any efforts to regroup" of IS subsequent to its military defeat at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank all the members of the UK armed forces who took part in this operation for their professionalism and their courage," he added. "They were among a great many UK service members stationed over the holidays. This action, to eliminate dangerous terrorists who threaten our way of life, highlights how British military are ready to step up, throughout the year, keeping Britain secure at home and powerful internationally."
In December, the US military conducted what it called a "major assault" against IS targets in the country, after an attack resulted in the deaths of two US troops and a local interpreter in Palmyra.
The United Nations reports Islamic State still maintains an estimated 5,000 to 7,000 combatants in Syria and Iraq.
